Program
What is our Symposium about
- We promote interdisciplinary conversations and strengthen research network.
- We identify new pathogenic targets, biomarkers, and intricate signallingpathways to provide a comprehensive perspective on disease pathogenesis.
- We propose and pioneer new therapeutic strategies.
Program
| 12:00 p.m. – 2:00 p.m. | Welcome Address / Lunch + Poster I / Industry I | Programme item |
| 2:00 p.m. – 3:20 p.m. | Session I: Autoimmune Disease and the Role of Autoantibodies Chairs: Prof. Dr. G. Riemekasten, Prof. Dr. C. Scheibenbogen |
Session |
| 2:00 p.m. – 2:10 p.m. | Welcome UzL Präsidium |
Programme item |
| 2:10 p.m. – 2:30 p.m. | Keynote: Concepts of autoimmunity Prof. Dr. Y. Shoenfeld |
Talk |
| 2:30 p.m. – 2:50 p.m. | G protein-coupled receptor autoantibody network in regulation of inflammation Prof. Dr. G. Riemekasten |
Talk |
| 2:50 p.m. – 3:05 p.m. | Antibodies targeting G protein-coupled receptors in health and disease Prof. Dr. O. Cabral-Marques (remote) |
Talk |
| 3:05 p.m. – 3:20 p.m. | Basic characterization of the neutrophil complement component 5a receptor and its role in vasculitis Prof. Dr. L. Björkman |
Talk |
| 3:20 p.m. – 4:00 p.m. | Coffee Break / Industry | Break |
| 4:00 p.m. – 5:30 p.m. | Session II: Autoantibody-Induced Disease Mechanisms Chairs: Prof. Dr. Y. Shoenfeld, Dr. A. Hackel |
Session |
| 4:00 p.m. – 4:15 p.m. | G protein-coupled receptor autoantibodies as allosteric modulators, vasculopathy Prof. Dr. D. Veprintsev |
Talk |
| 4:15 p.m. – 4:30 p.m. | G protein-coupled receptor-directed autoantibodies in glomerular diseases: Toward novel biomarkers and precision nephrology Prof. Dr. M. Banasik |
Talk |
| 4:30 p.m. – 4:45 p.m. | G protein-coupled receptor autoantibodies in early systemic sclerosis Dr. J. Ohmes |
Talk |
| 4:45 p.m. – 5:00 p.m. | Autoantibody-mediated angiotensin II type 1 receptor activation induces endothelial dysfunction in systemic sclerosis Dr. R. Akbarzadeh / C. Schmidt / L. Sommer |
Talk |
| 5:00 p.m. – 5:15 p.m. | G protein-coupled receptor autoantibodies in rheumatoid arthritis D. Miranda-Prieto |
Talk |
| 5:15 p.m. – 5:30 p.m. | Anti-beta 2 adrenergic receptor autoantibodies promote the development of primary Sjögren syndrome by its antagonistic effect Prof. Dr. X. Yue |
Talk |
| 9:00 a.m. – 11:00 a.m. | Session III: Organ-Specific Autoantibody Pathology Chairs: Prof. Dr. D. Veprintsev Dr. R. Akbarzadeh |
Session |
| 9:00 a.m. – 9:15 a.m. | Pathogenic and regulatory autoantibodies in multiple sclerosis, neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease Prof. Dr. F. Paul |
Talk |
| 9:15 a.m. – 9:30 a.m. | TSHR autoantibodies and their potential role in hypothalamic regulation Dr. H. Müller-Fielitz |
Talk |
| 9:30 a.m. – 9:45 a.m. | Keratinocyte-targeting functional autoantibodies in systemic sclerosis are associated with interstitial lung disease Dr. J. Wax |
Talk |
| 9:45 a.m. – 10:00 a.m. | Complement component 5a receptor-targeting antibodies and their relevance in vasculitis beyond antineutrophil cytoplasmic antibody-associated vasculitis Dr. S. Klapa (remote) |
Talk |
| 10:00 a.m. – 10:15 a.m. | G protein-coupled receptor autoantibodies in transplantation Dr. G. Moll |
Talk |
| 10:15 a.m. – 10:30 a.m. | Functional characterisation of G protein-coupled receptor-directed non-human leukocyte antigen antibodies in kidney transplantation Dr. M. Adu Gyamfi |
Talk |
| 10:30 a.m. – 10:45 a.m. | Autoantibody-driven disease severity in psoriatic arthritis L. Berg / Dr. H. Grasshoff |
Talk |
| 10:45 a.m. – 11:00 a.m. | Coagulation beyond clotting: the clot thickens – regulation of organ function by coagulation protease signalling Prof. Dr. B. Isermann |
Talk |
| 11:00 a.m. – 11:45 a.m. | Extended Coffee Break, Industry II and Poster Session II | Break / exhibition |
| 11:45 a.m. – 1:20 p.m. | Session IV: Autoantibodies in Fatigue and Neurological Disorders Chairs: Prof. Dr. T. Sakmar, Dr. H. Grasshoff |
Session |
| 11:45 a.m. – 12:05 p.m. | Autoantibodies in post-coronavirus disease 2019 syndrome and myalgic encephalomyelitis/chronic fatigue syndrome Dr. F. Sotzny |
Talk |
| 12:05 p.m. – 12:20 p.m. | Myalgic encephalomyelitis/chronic fatigue syndrome – the role of autoimmunity and antibody-targeting therapies Prof. Dr. C. Scheibenbogen |
Talk |
| 12:20 p.m. – 12:35 p.m. | Myalgic encephalomyelitis/chronic fatigue syndrome, a neurodegenerative autoimmune disease? Dr. A. Hackel |
Talk |
| 12:35 p.m. – 12:50 p.m. | Biased beta-2 adrenergic receptor signaling induced by functional autoantibodies in post-coronavirus disease 2019 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome N. Al Arawe |
Talk |
| 12:50 p.m. – 1:05 p.m. | The brain endothelial G protein-coupled receptor signaling as link between autoimmune diseases and cognitive impairment Dr. J. Wenzel (remote) |
Talk |
| 1:05 p.m. – 1:20 p.m. | Functional autoantibody alterations across the lifespan in myalgic encephalomyelitis/chronic fatigue syndrome M. Vollert / Dr. A. Hackel |
Talk |
| 1:20 p.m. – 3:00 p.m. | Lunch Session: Scientific Impulse Talks, Industry III, Poster Session III & Networking Lunch | Lunch session / exhibition |
| 1:20 p.m. – 1:25 p.m. | Autoantibody-mediated dysregulation of beta-2 adrenergic receptor expression in myalgic encephalomyelitis/chronic fatigue syndrome F. Hoheisel |
Impulse Talk |
| 1:25 p.m. – 1:30 p.m. | Investigating the effects of agonistic angiotensin II type 1 receptor autoantibodies on retinal vascular and neuronal function in vitro and in vivo S. Zare |
Impulse Talk |
| 1:30 p.m. – 1:35 p.m. | Effects of angiotensin II type 1 receptor-targeting autoantibodies on brain endothelial cells L. Kleindienst |
Impulse Talk |
| 1:35 p.m. – 1:40 p.m. | Gold-enabled high-resolution imaging of G protein-coupled receptor autoantibody binding cells K. Werner |
Impulse Talk |
| 1:40 p.m. – 1:45 p.m. | IgG glycosylation in systemic sclerosis H. F. Schumacher, P. Köcher, K. Manzhula, E. L. Lienesch, Prof. Dr. Marc Ehlers |
Impulse Talk |
| 1:45 p.m. – 1:50 p.m. | MEK1/2 inhibition ameliorates clinical lesions in experimental pemphigus vulgaris Dr. S. Emtenani |
Impulse Talk |
| 1:50 p.m. – 3:00 p.m. | Networking Lunch, Poster Session III and Industry III | Break / exhibition |
| 3:00 p.m. – 5:10 p.m. | Session V: Precision Medicine & Diagnostics Chairs: Prof. Dr. M. Banasik, Prof. Dr. F. Petersen |
Session |
| 3:00 p.m. – 3:20 p.m. | Keynote: Multiplexed anti-G protein-coupled receptor antibody validation strategies Prof. Dr. T. Sakmar |
Talk |
| 3:20 p.m. – 3:35 p.m. | G protein-coupled receptor autoantibodies as biomarker in systemic sclerosis Dr. S. Schinke |
Talk |
| 3:35 p.m. – 3:50 p.m. | Combining optical technology with autoantibodies, systemic sclerosis, psoriatic arthritis Dr. H. Grasshoff |
Talk |
| 3:50 p.m. – 4:05 p.m. | Distinct extracellular vesicle signatures association with G protein-coupled receptor autoantibodies in systemic sclerosis P. Bonney |
Talk |
| 4:05 p.m. – 4:25 p.m. | Coffee Break | Break |
| 4:25 p.m. – 4:40 p.m. | G protein-coupled receptor autoantibodies in cardiovascular diseases Prof. Dr. T. Zeller |
Talk |
| 4:40 p.m. – 4:55 p.m. | Distinct Autoantibody Profiles Targeting G-Protein-Coupled Receptors in Subgroups of a Large Post-infectious ME/CFS Cohort J. Schmitz |
Talk |
| 4:55 p.m. – 5:10 p.m. | Endothelin type A receptor-related markers may be important factors identifying patients at higher risk of long-term kidney allograft loss K. Jakuszko |
Talk |
| 5:10 p.m. – 5:25 p.m. | Farewell | Programme End |